Bisoprolol Fumarate
Bisoprolol Fumarate is a cardioselective beta-1 blocker used primarily to treat hypertension, heart failure, and angina. It works by reducing heart rate and the force of heart contractions, thereby lowering blood pressure and decreasing the heart's workload.
A beta-blocker used to treat high blood pressure, heart failure, and chest pain by reducing heart rate and cardiac workload.
Key facts at a glance
- RxNorm
- 142146
- Generic
- Bisoprolol Fumarate
- Class
- pin-variant
- Brands
- Ziac
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteravoid if possible
avoid use during pregnancy unless benefits outweigh risks
regular fetal monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
second trimesteravoid if possible
discontinue use or switch to safer alternative
fetal growth monitoring and heart rate assessment
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
third trimesteravoid if possible
avoid use near delivery due to risk of neonatal bradycardia and hypotension
fetal monitoring and assessment of neonatal status at birth
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
breastfeedingavoid
bisoprolol is excreted in breast milk; breastfeeding should be avoided or infant should be monitored closely
monitor infant for signs of bradycardia and hypotension
Use of this medication in this population requires careful consideration of risks and benefits.
pediatric_age
children under 12not recommended
safety and efficacy not established in pediatric patients; use not recommended
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
geriatric
elderly 65 years and olderstart at lowest dose
initiate therapy at low dose and titrate slowly; monitor for excessive bradycardia and hypotension
regular monitoring of blood pressure and heart rate
Use with caution and monitor for adverse effects.
renal_impairment
severe creatinine clearance less than 30 ml minreduce dose by 50%
use with caution; dose reduction recommended in severe renal impairment
monitor renal function and adjust dose accordingly
Use with caution and monitor for adverse effects.
hepatic_impairment
severe hepatic impairmentreduce dose by 50%
use with caution; dose reduction recommended in severe hepatic impairment
monitor liver function and blood pressure response
Use with caution and monitor for adverse effects.
Statistics and clinical data
Drug class
Beta-1 selective adrenergic blocking agent
Common uses
Therapeutic indications for bisoprolol fumarate
FDA approval year
Initial FDA approval date for bisoprolol fumarate
Mechanism of action
Pharmacodynamic mechanism of action
Treatment of hypertension (high blood pressure), chronic heart failure, and stable angina (chest pain). May be used alone or with other medications.
Selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, cardiac output, and blood pressure. Its cardioselective nature means it primarily affects the heart with minimal effect on beta-2 receptors in the lungs and blood vessels.
Do not stop taking suddenly without medical supervision as this can worsen heart conditions. May mask symptoms of low blood sugar in diabetics. Inform your doctor of any breathing problems, bradycardia, or severe heart block before starting therapy. Alcohol may enhance blood pressure-lowering effects.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy