Bisoprolol / Hydrochlorothiazide
Bisoprolol/Hydrochlorothiazide is a combination medication used to treat high blood pressure (hypertension). It contains two active ingredients that work through different mechanisms to lower blood pressure - one reduces heart rate and heart workload, while the other helps the body eliminate excess fluid. This combination may be prescribed when single-agent blood pressure therapy is not sufficient.
A two-drug blood pressure medication combining a beta-blocker with a diuretic to lower hypertension through complementary actions.
Key facts at a glance
- RxNorm
- 214317
- Generic
- Bisoprolol / Hydrochlorothiazide
- Class
- multi-ingredient
- Brands
- Ziac
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of essential hypertension (high blood pressure) in patients who require combination therapy when single-agent treatment is inadequate.
Bisoprolol is a beta-1 selective blocker that reduces heart rate and the force of heart contractions, decreasing cardiac output. Hydrochlorothiazide is a thiazide diuretic that promotes renal excretion of sodium and water, reducing plasma volume. Together they provide additive antihypertensive effects.
May cause dizziness or fatigue; avoid alcohol; do not stop taking suddenly as this may worsen angina or cause rebound hypertension; inform your doctor of any kidney, liver, or heart problems; monitor for signs of low potassium or electrolyte imbalances. Not recommended during pregnancy.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy