Belantamab Mafodotin
Blenrep is a prescription medication used to treat adults with multiple myeloma that has returned or not responded to previous treatments. It is an antibody-drug conjugate that targets BCMA, a protein found on multiple myeloma cells, and delivers a chemotherapy agent directly to those cells to destroy them.
Blenrep is a targeted therapy for relapsed or refractory multiple myeloma that delivers chemotherapy directly to cancer cells.
Key facts at a glance
- RxNorm
- 2387839
- Generic
- Blenrep
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Blenrep is indicated for the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.
Blenrep is a B-cell maturation antigen (BCMA)-directed antibody-drug conjugate. The monoclonal antibody component binds to BCMA on the surface of multiple myeloma cells. The conjugate is then internalized, releasing the cytotoxic agent (mafodotin) inside the cell, which disrupts microtubule function and leads to cell death.
Blenrep carries a boxed warning for ocular toxicity, including keratopathy (corneal deposits) and changes in visual acuity. Regular ophthalmologic examinations are required before and during treatment. Common side effects include thrombocytopenia, anemia, infusion-related reactions, and blurred vision. This medication is administered intravenously by a healthcare professional.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed September 3, 2026. · Read our editorial policy