Blinatumomab
Blinatumomab is a bispecific T-cell engager antibody used to treat certain types of acute lymphoblastic leukemia (ALL). It works by simultaneously binding to CD19 on cancer cells and CD3 on T-cells, bringing them together so the T-cells can recognize and destroy the malignant B-cells. This medication is primarily used for B-cell ALL that is refractory or in remission but with detectable minimal residual disease.
Blinatumomab is an immunotherapy drug that directs the body's own T-cells to attack and kill CD19-positive B-cell leukemia cells.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L01FX07
- RxNorm
- 1597258
- Generic
- Blinatumomab
- Class
- atc-l01
- Brands
- Blincyto
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of B-cell acute lymphoblastic leukemia (ALL) in adults and children, including those with minimal residual disease (MRD) positive disease and relapsed/refractory disease.
As a bispecific CD19-directed CD3 T-cell engager, blinatumomab binds to CD19 on B-lineage cells and CD3 on T-cells, forming a bridge that activates T-cells to recognize and kill the malignant B-cells.
Administered as a continuous intravenous infusion over extended periods. Requires close monitoring in a healthcare setting due to risks of cytokine release syndrome (CRS), neurological toxicity, and infections. Patients should be premedicated and monitored for signs of cytokine release, especially during the first cycle of treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy