Doxylamine and Pyridoxine
Bonjesta is a prescription medication combining doxylamine and pyridoxine (vitamin B6) to treat nausea and vomiting during pregnancy. It is specifically designed for pregnant women experiencing severe morning sickness that does not respond to conservative measures like dietary changes. This delayed-release formulation helps manage symptoms throughout the day.
Bonjesta is a prescription anti-nausea medication for pregnant women with severe morning sickness.
Key facts at a glance
- RxNorm
- 1999652
- Generic
- Bonjesta
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Bonjesta is indicated for the treatment of nausea and vomiting of pregnancy (morning sickness) in women who have not responded to conservative management strategies. It is prescribed when symptoms are severe enough to potentially affect hydration, nutrition, or daily functioning.
Bonjesta combines doxylamine succinate, an antihistamine with anticholinergic properties that helps reduce nausea and vomiting, with pyridoxine hydrochloride (vitamin B6), which may help address vitamin deficiency that can contribute to pregnancy-related nausea. The delayed-release formulation allows gradual release of the active ingredients.
Bonjesta is FDA-approved for use during pregnancy and is typically initiated at a low dose, adjusted as needed. Common side effects include drowsiness, dizziness, and dry mouth. Women should use caution when driving or operating machinery until they understand how the medication affects them. It should be taken on an empty stomach with water.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed September 3, 2026. · Read our editorial policy