Bopindolol Hydrogen Malonate
Bopindolol Hydrogen Malonate is a non-selective beta-blocker with intrinsic sympathomimetic activity, used primarily for the treatment of hypertension. It works by blocking beta-adrenergic receptors while also providing mild partial agonist effects, making it suitable for patients who may not tolerate traditional beta-blockers.
A beta-blocker medication used to treat hypertension, with unique partial agonist properties that may offer advantages for certain patients.
Key facts at a glance
- RxNorm
- 236903
- Generic
- Bopindolol Hydrogen Malonate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
10 groupspregnancy
first trimesteravoid if possible
use only if benefits outweigh potential risks to fetus
regular fetal monitoring including heart rate
Use with caution and monitor for adverse effects.
pregnancy
second third trimesterreduce dose to lowest effective
continue only if essential, monitor fetal growth
regular fetal ultrasound and heart rate monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedinguse lowest effective dose
monitor infant for signs of beta-blockade
observe infant for bradycardia, hypotension, hypoglycemia
Use with caution and monitor for adverse effects.
geriatric
elderly over 65start at 0.5mg once daily
initiate at low dose and titrate slowly
monitor blood pressure, heart rate, renal function
Use with caution and monitor for adverse effects.
pediatric_age
children under 12not recommended
use is not recommended in pediatric population
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
pediatric_age
adolescents 12 18use with caution
limited data available, use only if clearly needed
monitor growth, development, vital signs
Use with caution and monitor for adverse effects.
renal_impairment
mild moderatereduce dose by 25-50%
monitor renal function and adjust dose accordingly
regular monitoring of renal function and electrolytes
Use with caution and monitor for adverse effects.
renal_impairment
severereduce dose by 50% or use alternative
use with extreme caution, consider alternative therapy
close monitoring of renal function, electrolytes, blood pressure
Use with caution and monitor for adverse effects.
hepatic_impairment
mild moderatereduce dose by 25-50%
use with caution, monitor liver function tests
monitor liver function tests and clinical response
Use with caution and monitor for adverse effects.
hepatic_impairment
severereduce dose by 50% or avoid
use only if benefits outweigh risks, consider alternative
frequent monitoring of liver function and clinical status
Use with caution and monitor for adverse effects.
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Drug class information
Common uses
Common therapeutic uses
Mechanism of action
Primary pharmacological mechanism
Primarily used for the management of hypertension (high blood pressure). May also be used for angina pectoris (chest pain) in some regions.
Bopindolol is a non-selective beta-blocker that blocks both beta-1 and beta-2 adrenergic receptors. It also possesses intrinsic sympathomimetic activity (partial agonist properties), meaning it can produce some beta-receptor stimulation while primarily blocking the effects of catecholamines.
Like other beta-blockers, it should not be discontinued abruptly. Caution is advised in patients with asthma, diabetes, or certain heart conditions. Dosing is typically once daily. Medical supervision is required for proper evaluation and monitoring.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy