Bordetella Pertussis Pertactin Vaccine, Inactivated
The Bordetella Pertussis Pertactin Vaccine is an inactivated vaccine targeting the pertactin protein, a virulence factor found on the surface of Bordetella pertussis bacteria. This vaccine is designed to stimulate immune protection against pertussis (whooping cough) by inducing antibodies against the pertactin component. It represents a component of acellular pertussis vaccine technology used in immunization programs.
An inactivated vaccine providing immunity against pertussis (whooping cough) by targeting the pertactin protein of Bordetella pertussis.
Key facts at a glance
- RxNorm
- 1300184
- Generic
- Bordetella Pertussis Pertactin Vaccine, Inactivated
- Class
- pin-variant
- Brands
- Quadracel, Vaxelis, Infanrix, Daptacel, Boostrix, Adacel
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
7 groupspregnancy
general pregnancynone
Tdap vaccination recommended during every pregnancy, preferably between 27-36 weeks gestation to maximize antibody transfer to fetus
standard prenatal care
pregnancy
first trimesternone
vaccination can be administered if needed, but postponing until second or third trimester is preferred when possible
standard prenatal care
Use with caution and monitor for adverse effects.
lactation
breastfeeding mothersnone
vaccination recommended for breastfeeding mothers who have not previously received Tdap during current pregnancy
none
pediatric_age
infants 2 months to 6 yearsnone
routine DTaP vaccination recommended starting at 2 months of age according to childhood immunization schedule
standard pediatric well-child visits
geriatric
elderly 65 years and oldernone
Tdap booster recommended for adults 65 years and older who have not previously received Tdap; revaccination with Td every 10 years
standard geriatric assessment
renal_impairment
chronic kidney diseasenone
no dosage adjustment needed; patients with renal impairment should receive standard vaccination schedule
standard monitoring
hepatic_impairment
liver diseasenone
no dosage adjustment needed; patients with hepatic impairment should receive standard vaccination schedule
standard monitoring
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Vaccine classification
Common uses
Therapeutic indication
Estimated vaccine efficacy
Clinical efficacy data
Prevention of pertussis (whooping cough) caused by Bordetella pertussis infection. May be used as part of combination pertussis-containing vaccines in pediatric immunization schedules or in outbreak situations where targeted protection is needed.
The vaccine contains inactivated pertactin, an outer membrane protein of Bordetella pertussis. Upon administration, it stimulates the immune system to produce specific antibodies against pertactin, which helps neutralize the bacterium and prevent colonization and disease progression.
As with all vaccines, complete immunization may not guarantee protection in all individuals. Some Bordetella pertussis strains have shown reduced or absent pertactin expression. Should be administered according to regional immunization guidelines by qualified healthcare professionals. Contraindications include severe allergic reactions to vaccine components.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy