Bosutinib
Bosutinib is a tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML) by targeting the BCR-ABL protein and Src-family kinases that drive cancer cell growth. It is particularly effective against imatinib-resistant forms of CML.
A targeted therapy for chronic myeloid leukemia that inhibits BCR-ABL and Src kinases, including imatinib-resistant forms.
Key facts at a glance
- ATC
- L01EA04
- RxNorm
- 1307619
- Generic
- Bosutinib
- Class
- atc-l01
- Brands
- Bosulif
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in adult patients who are resistant or intolerant to prior therapy, including imatinib.
Bosutinib inhibits the BCR-ABL tyrosine kinase (the abnormal protein driving CML) and also blocks Src-family kinases including Src, Lyn, and Hck. This dual inhibition disrupts signals that promote cancer cell proliferation and survival.
Take with food; common side effects include diarrhea, nausea, and rash. Requires regular blood count and liver function monitoring. May cause fluid retention, QT prolongation, and cardiac events. Avoid in patients with hepatic impairment. Drug interactions with strong CYP3A inhibitors/inducers should be considered.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy