Brigatinib
Brigatinib is a tyrosine kinase inhibitor used primarily to treat ALK-positive non-small cell lung cancer. It works by blocking the activity of the anaplastic lymphoma kinase (ALK) protein and other related kinases, which can slow or stop the growth of cancer cells.
Brigatinib is an ALK inhibitor used to treat certain types of advanced non-small cell lung cancer.
Key facts at a glance
- ATC
- L01ED04
- RxNorm
- 1921217
- Generic
- Brigatinib
- Class
- atc-l01
- Brands
- Alunbrig
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Treatment of adults with ALK-positive metastatic non-small cell lung cancer who have progressed on or are intolerant to crizotinib. May also be used in patients who have not received prior ALK inhibitor therapy.
Brigatinib inhibits multiple tyrosine kinases including ALK, ROS1, IGF-1R, FLT-3, and mutant EGFR. By blocking ALK signaling, it inhibits cancer cell proliferation and survival in ALK-positive tumors.
May cause serious side effects including lung problems, hypertension, and visual disturbances. Requires regular monitoring of blood pressure and pulmonary symptoms. Should be taken as directed with or without food. Avoid grapefruit juice during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy