Brimonidine / Brinzolamide
Brimonidine/Brinzolamide is a combination eye drop medication used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It combines two pressure-lowering agents that work through different mechanisms to reduce fluid production in the eye. This combination therapy is typically prescribed when single-agent therapy is insufficient.
A combination eye drop medication that lowers eye pressure in glaucoma patients by combining two different pressure-reducing agents.
Key facts at a glance
- RxNorm
- 1421450
- Generic
- Brimonidine / Brinzolamide
- Class
- multi-ingredient
- Brands
- Simbrinza
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Open-angle glaucoma, ocular hypertension, and other forms of elevated intraocular pressure when single-agent therapy provides inadequate control.
Brimonidine is an alpha-2 adrenergic agonist that decreases aqueous humor production, while Brinzolamide is a carbonic anhydrase inhibitor that also reduces aqueous humor production. Together, they provide complementary pressure-lowering effects through different pathways.
For ophthalmic use only. May cause eye redness, irritation, blurred vision, dry mouth, or altered taste. Contraindicated in patients with hypersensitivity to either component. Use with caution in patients with depression, cardiovascular disease, or orthostatic hypotension. Wait at least 5-10 minutes between using different eye products if prescribed together.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy