Brincidofovir
Brincidofovir is an antiviral medication designed specifically to treat infections caused by the variola virus, which is the virus responsible for smallpox. It belongs to the ATC J05 class of antiviral drugs for systemic use. While smallpox has been eradicated in the wild, this medication remains an important therapeutic option for confirmed cases and is also maintained in national strategic stockpiles for public health preparedness.
Brincidofovir is an antiviral drug used to treat smallpox (variola virus) infections and is maintained in strategic national stockpiles for public health emergency preparedness.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- J05AB17
- RxNorm
- 2599518
- Generic
- Brincidofovir
- Class
- atc-j05
- Brands
- Tembexa
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- suspension, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Brincidofovir is indicated for the treatment of smallpox, a serious viral disease caused by the variola virus. Due to the eradication of smallpox in the general population, it is primarily used in confirmed clinical cases or outbreak scenarios and maintained as part of national preparedness stockpiles.
Brincidofovir exerts its antiviral effects by targeting the variola virus. The medication interferes with viral replication processes, helping to reduce viral load and control the spread of infection within the body.
Brincidofovir is specifically approved under the FDA for smallpox treatment. It is not indicated for routine use against other viral infections. As with all antiviral medications, its use should be guided by healthcare professionals aware of the patient's complete medical history and potential drug interactions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy