Bromodiphenhydramine Hydrochloride
Bromodiphenhydramine Hydrochloride is a first-generation antihistamine with anticholinergic properties. It was used to treat allergic conditions such as hay fever, allergic rhinitis, and cold symptoms, as well as for motion sickness and as a sleep aid. The medication has been withdrawn from many markets due to safety concerns and is not commonly prescribed today.
A sedating first-generation antihistamine previously used for allergies, cold symptoms, and sleep that has been largely discontinued due to safety concerns.
Key facts at a glance
- RxNorm
- 91065
- Generic
- Bromodiphenhydramine Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Relief of allergic symptoms (hay fever, rhinitis, itching, watery eyes), common cold symptoms, motion sickness prevention, and temporary sleep assistance. Note: This medication has been discontinued in many countries due to safety concerns.
Blocks H1 histamine receptors in the body, preventing histamine from causing allergic symptoms. Additionally has anticholinergic effects that contribute to its sedating properties and ability to reduce secretions.
Causes significant drowsiness; avoid operating machinery or driving. Should not be combined with alcohol, sedatives, or other anticholinergic medications. Contraindicated in angle-closure glaucoma, urinary retention, and severe heart disease. Use with caution in elderly patients due to anticholinergic effects. This medication has been withdrawn from the US market and many international markets.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy