Brompheniramine / Diphenhydramine / Phenylephrine
This combination medication contains two antihistamines (brompheniramine and diphenhydramine) along with a decongestant (phenylephrine) to address multiple cold and allergy symptoms. It is typically used to temporarily relieve nasal congestion, sneezing, runny nose, itchy eyes, and other symptoms associated with the common cold, seasonal allergies, or sinus congestion.
A multi-ingredient cold and allergy medication that combines antihistamines with a decongestant to relieve congestion and other respiratory symptoms.
Key facts at a glance
- RxNorm
- 834774
- Generic
- Brompheniramine / Diphenhydramine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms of the common cold, seasonal allergies, hay fever, and sinus congestion including nasal stuffiness, sneezing, runny nose, itchy nose/throat/eyes, and watery eyes.
The antihistamines (brompheniramine and diphenhydramine) block histamine H1 receptors to reduce allergic symptoms, while phenylephrine acts as a alpha-adrenergic agonist that constricts blood vessels in the nasal passages to reduce swelling and congestion.
May cause significant drowsiness; avoid alcohol and use caution when driving or operating machinery. Not recommended for children under certain ages without medical advice. Consult a healthcare provider before use if you have glaucoma, enlarged prostate, thyroid disorders, high blood pressure, or are taking other medications. Do not use with MAO inhibitors.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy