Buclizine
Buclizine is an antihistamine medication primarily used to prevent and treat nausea, vomiting, and vertigo associated with motion sickness. It belongs to the piperazine class of antihistamines and works by blocking histamine H1 receptors and affecting the vestibular system. The medication is typically taken before travel to prevent symptoms of motion sickness.
Buclizine is an antihistamine used to prevent motion sickness-related nausea and vertigo.
Key facts at a glance
- ATC
- R06AE01
- RxNorm
- 59636
- Generic
- Buclizine
- Class
- atc-r06
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention and treatment of motion sickness; management of nausea, vomiting, and vertigo; may also be used for allergic conditions due to its antihistamine properties.
Buclizine is an H1 receptor antagonist that blocks histamine action. It also has anticholinergic properties which help suppress vestibular stimulation and reduce nausea and vomiting signals in the brain.
May cause drowsiness and sedation; use with caution when operating machinery or driving. Should be avoided or used with caution in patients with glaucoma, urinary retention, benign prostatic hyperplasia, or during pregnancy. Alcohol may enhance sedative effects.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy