Aspirin
Bufferin is an over-the-counter brand-name analgesic containing buffered aspirin (acetylsalicylic acid) combined with an antacid to help reduce stomach irritation. It is commonly used for temporary relief of minor aches, pains, fever, and headaches. The buffering agent (typically calcium carbonate or similar) is designed to make the aspirin gentler on the stomach lining.
Bufferin is a buffered aspirin product used for temporary relief of minor aches, pains, and fever.
Key facts at a glance
- RxNorm
- 215770
- Generic
- Bufferin
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for temporary relief of minor aches and pains including headache, muscle pain, toothache, menstrual cramps, and fever. Also sometimes used for anti-inflammatory purposes and cardiovascular protection as directed by a healthcare provider.
Contains aspirin (acetylsalicylic acid), which works by inhibiting cyclooxygenase (COX) enzymes to reduce the production of prostaglandins—chemicals involved in pain, inflammation, and fever. The buffered formulation includes an antacid to neutralize stomach acid and help reduce gastric irritation.
Should not be given to children or teenagers with viral infections due to Reye's syndrome risk. Not suitable for individuals allergic to aspirin or other NSAIDs. May interact with blood thinners, other NSAIDs, and certain blood pressure medications. Patients with ulcers, bleeding disorders, or asthma should consult a healthcare provider before use. Always read the label and do not exceed recommended doses.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed September 3, 2026. · Read our editorial policy