Bulevirtide
Bulevirtide is an antiviral medication designed to treat chronic hepatitis D virus (HDV) infection in adults with compensated liver disease. It works by blocking the entry of the hepatitis D virus into liver cells, reducing viral load and helping to improve liver function over time.
Bulevirtide is an antiviral injection used to treat chronic hepatitis D infection by preventing the virus from entering liver cells.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- J05AX28
- RxNorm
- 2743603
- Generic
- Bulevirtide
- Class
- atc-j05
- Brands
- Hepcludex
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Bulevirtide is indicated for the treatment of chronic hepatitis D virus (HDV) infection in adults with compensated liver disease. It is used when hepatitis B virus is also present (HDV/HBV coinfection).
Bulevirtide is a viral entry inhibitor that blocks the sodium taurocholate co-transporting polypeptide (NTCP) receptor on hepatocytes. By inhibiting this receptor, it prevents hepatitis D virus from entering liver cells, thereby reducing viral replication and infection of new cells.
Bulevirtide is administered as a subcutaneous injection, typically once daily. Common side effects may include injection site reactions and elevated bile acid levels. Treatment should be initiated and monitored by a physician experienced in managing hepatitis infections. Regular monitoring of viral load and liver function is recommended during therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy