Bupivacaine / Meloxicam
Bupivacaine/Meloxicam is a combination medication pairing a long-acting local anesthetic with a non-steroidal anti-inflammatory drug (NSAID). This combination provides both immediate numbing relief and sustained anti-inflammatory action for targeted pain management.
A local anesthetic and NSAID combination used to relieve pain by blocking nerve signals and reducing inflammation at the site of application.
Key facts at a glance
- RxNorm
- 2560310
- Generic
- Bupivacaine / Meloxicam
- Class
- multi-ingredient
- Brands
- Zynrelef
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for localized pain relief in conditions involving both inflammatory and nociceptive pain components, such as musculoskeletal injuries, post-procedural pain, or joint pain when administered in approved formulations like intra-articular or topical preparations.
Bupivacaine blocks sodium channels in nerve fibers, preventing pain signal transmission and providing local numbness. Meloxicam inhibits COX-2 enzymes to reduce prostaglandin production, decreasing inflammation and associated pain at the site.
As a combination product, safety considerations include local anesthetic toxicity from bupivacaine (cardiac effects at high doses) and standard NSAID risks (GI effects, renal considerations, cardiovascular effects from meloxicam). Should only be used as directed by a healthcare professional; injection-site formulations require proper administration technique.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy