Buprenorphine / Naloxone
Buprenorphine/Naloxone is a combination medication used to treat opioid use disorder. The buprenorphine component helps reduce cravings and withdrawal symptoms by acting as a partial opioid agonist, while naloxone discourages misuse by blocking opioid effects if the medication is injected. This medication is typically prescribed as part of a comprehensive treatment program that includes counseling and behavioral therapy.
A medication used to treat opioid dependence by reducing cravings and preventing misuse through combined partial opioid agonist and antagonist effects.
Key facts at a glance
- RxNorm
- 352364
- Generic
- Buprenorphine / Naloxone
- Class
- multi-ingredient
- Brands
- Zubsolv, Bunavail, Suboxone
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of opioid use disorder in adults. Used for both maintenance treatment and short-term detoxification from opioids such as heroin, fentanyl, and prescription opioid medications. Part of a broader medication-assisted treatment (MAT) approach that should include psychosocial support.
Buprenorphine is a partial mu-opioid receptor agonist that helps manage withdrawal symptoms and cravings without producing the full effects of full opioid agonists. Naloxone is an opioid antagonist that has minimal effect when taken sublingually but blocks opioid receptors if the medication is misused through injection, helping to deter abuse.
Should only be initiated when mild-to-moderate withdrawal is present to avoid precipitated withdrawal. Can cause respiratory depression, especially when combined with benzodiazepines, alcohol, or other CNS depressants. Has potential for dependence itself and must be prescribed by a certified healthcare provider. Diversion and misuse can occur. Patients should be monitored regularly and stored securely away from children and others.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy