Bupropion / Dextromethorphan
Bupropion/dextromethorphan is an oral combination medication approved for treating major depressive disorder in adults. It combines an atypical antidepressant with a cough suppressant that also has mood-elevating properties, working through multiple neurotransmitter pathways.
An oral combination antidepressant approved for adults with major depressive disorder, utilizing two medications with complementary mechanisms of action.
Key facts at a glance
- RxNorm
- 2611256
- Generic
- Bupropion / Dextromethorphan
- Class
- multi-ingredient
- Brands
- Auvelity
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily prescribed for major depressive disorder (MDD) in adults, including treatment-resistant depression. It offers a rapid-onset option for patients who need faster relief from depressive symptoms.
Dextromethorphan acts on sigma-1 receptors and NMDA glutamate receptors, while bupropion inhibits norepinephrine and dopamine reuptake. Bupropion also slows the breakdown of dextromethorphan by inhibiting CYP2D6, allowing sustained antidepressant effects.
May cause dizziness, dry mouth, or sexual side effects. Contraindicated in patients with seizure disorders, eating disorders, or those using MAO inhibitors. Patients should avoid alcohol. Effects on blood pressure and heart rate should be monitored. Not recommended during pregnancy without careful benefit-risk assessment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy