Bupropion Hydrochloride
Bupropion Hydrochloride is an atypical antidepressant and smoking cessation aid that works by inhibiting the reuptake of norepinephrine and dopamine in the brain. It is primarily prescribed for the treatment of major depressive disorder, seasonal affective disorder, and to support smoking cessation by reducing nicotine cravings and withdrawal symptoms.
Bupropion is a norepinephrine-dopamine reuptake inhibitor used to treat depression and aid smoking cessation.
Key facts at a glance
- RxNorm
- 203204
- Generic
- Bupropion Hydrochloride
- Class
- pin-variant
- Brands
- Forfivo, Contrave, Auvelity, Wellbutrin
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Bupropion is FDA-approved for treating major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid for smoking cessation under the brand name Zyban. It may also be used off-label for conditions such as attention deficit hyperactivity disorder (ADHD) and bipolar depression.
As a norepinephrine-dopamine reuptake inhibitor (NDRI), bupropion blocks the reuptake transporters for both norepinephrine and dopamine, increasing their availability in the synaptic cleft. It has minimal activity on serotonin systems, which distinguishes it from most other antidepressants.
Bupropion is contraindicated in patients with seizure disorders, eating disorders (bulimia or anorexia), or those undergoing abrupt alcohol/sedative withdrawal. It carries a risk of lowering seizure threshold and should not exceed recommended doses. Common side effects include insomnia, dry mouth, headache, and nausea. The extended-release formulation must be swallowed whole to avoid dose-dumping. It may take 4-6 weeks to achieve full therapeutic effect.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy