Buthiazide / Dihydralazine / Metipranolol
This combination medication contains three active ingredients - a thiazide diuretic (Buthiazide), a vasodilator (Dihydralazine), and a beta-blocker (Metipranolol). It is used to treat hypertension (high blood pressure) by targeting blood pressure regulation through multiple complementary mechanisms. The combination allows for synergistic effects at lower doses of individual components.
A triple-combination antihypertensive medication used to lower high blood pressure through diuretic, vasodilator, and beta-blocking actions.
Key facts at a glance
- RxNorm
- 1007307
- Generic
- Buthiazide / Dihydralazine / Metipranolol
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Essential hypertension (high blood pressure) when monotherapy or dual therapy is insufficient. May be considered when blood pressure requires multi-targeted approach for adequate control.
Buthiazide (thiazide diuretic) reduces fluid volume by increasing urinary sodium excretion; Dihydralazine relaxes arterial smooth muscle to reduce peripheral vascular resistance; Metipranolol (beta-blocker) decreases heart rate and cardiac output. Together they lower blood pressure through complementary mechanisms.
May cause electrolyte imbalances (especially low potassium), dizziness, or fatigue. Contraindicated in severe bradycardia, heart block, heart failure, and severe renal impairment. Avoid abrupt discontinuation of beta-blocker component. Regular monitoring of blood pressure, electrolytes, and renal function recommended. May interact with other antihypertensives, lithium, or NSAIDs.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy