Buthiazide / Reserpine
Buthiazide/Reserpine is a combination antihypertensive medication pairing a thiazide-like diuretic with an old-generation antihypertensive agent. This combination is used to treat high blood pressure (hypertension) in patients who require multiple mechanisms of action to control their blood pressure effectively. The diuretic component promotes fluid and salt elimination, while the other component reduces sympathetic nervous system activity to lower blood pressure.
A combination blood pressure medication using a diuretic and sympathetic inhibitor to treat hypertension.
Key facts at a glance
- RxNorm
- 1008543
- Generic
- Buthiazide / Reserpine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of hypertension (high blood pressure), typically when monotherapy is insufficient. May be considered for patients requiring multiple antihypertensive agents.
Buthiazide acts as a thiazide-like diuretic, promoting sodium and water excretion to reduce blood volume and vascular resistance. Reserpine depletes catecholamine stores in nerve terminals, decreasing sympathetic nervous system activity that contributes to elevated blood pressure.
May cause electrolyte imbalances (especially low potassium), drowsiness, or depression in some patients. Reserpine use requires monitoring for mood changes. Not typically used as first-line therapy in modern practice due to side effect profile and availability of better-tolerated alternatives. Regular blood pressure and electrolyte monitoring recommended.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy