C1 Esterase Inhibitor (Human)
C1 Esterase Inhibitor (Human) is a replacement therapy used to treat and prevent hereditary angioedema (HAE) attacks in patients with C1 inhibitor deficiency. This medication works by replenishing the deficient C1 inhibitor protein, which helps regulate bradykinin production and prevents the uncontrolled swelling episodes characteristic of the condition.
C1 Esterase Inhibitor (Human) is a protein replacement therapy for hereditary angioedema that prevents and treats swelling attacks by supplementing deficient C1 inhibitor.
Key facts at a glance
- RxNorm
- 809864
- Generic
- C1 Esterase Inhibitor (Human)
- Class
- pin-variant
- Brands
- Haegarda, Cinryze, Berinert
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and routine prophylaxis of hereditary angioedema (HAE) in adults, adolescents, and children due to C1 inhibitor deficiency. Used for acute abdominal attacks, facial/throat swelling, and peripheral edema.
C1 esterase inhibitor is a naturally occurring serine protease inhibitor. It regulates the complement and contact systems by inhibiting C1 esterase, kallikrein, and factor XIIa. In HAE patients with deficient C1-INH, replacement therapy restores inhibitory control, preventing excess bradykinin production that causes vascular permeability and angioedema.
Administered by intravenous infusion. Self-administration may be taught after proper training. Hypersensitivity reactions are possible; contraindicated with known anaphylaxis to C1 inhibitor products. Product is plasma-derived; theoretical infection risk exists. Thrombotic events have been reported with high-dose regimens. Dosing varies for acute treatment versus prophylaxis.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy