Cabotegravir Sodium
Cabotegravir Sodium is an integrase strand transfer inhibitor (INSTI) used for the treatment and prevention of HIV infection. Available as both a daily oral tablet and a long-acting injectable formulation, it offers flexible dosing options with injectable administration every one to two months after an initial loading period.
Cabotegravir Sodium is an HIV integrase inhibitor used for HIV treatment and prevention, available as daily oral tablets or long-acting injections.
Key facts at a glance
- RxNorm
- 2475076
- Generic
- Cabotegravir Sodium
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used in combination with rilpivirine as a complete regimen for HIV-1 infection in adults (marketed as Cabenuva for the injectable combination). Also approved for pre-exposure prophylaxis (PrEP) to reduce HIV risk in at-risk individuals, where the injectable formulation allows for every-two-month dosing after loading doses.
Cabotegravir inhibits HIV integrase, an essential viral enzyme required to integrate HIV DNA into the host cell's genome. By blocking this step in the viral replication cycle, it prevents the virus from establishing productive infection and reduces viral load.
The injectable formulation may cause injection site reactions including pain, nodules, or swelling. Requires strict adherence to dosing schedules; missed injections can lead to viral resistance. Oral lead-in therapy may be used to assess tolerability before starting injections. May interact with certain anticonvulsants, antibiotics, and corticosteroids. Patients should avoid becoming pregnant during treatment due to limited safety data.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy