Cabozantinib
Cabozantinib is a targeted cancer therapy that works as a tyrosine kinase inhibitor, blocking multiple enzymes involved in tumor growth and blood vessel formation. It is prescribed for certain types of cancer including renal cell carcinoma (kidney cancer), hepatocellular carcinoma (liver cancer), and medullary thyroid cancer.
Cabozantinib is a multi-kinase inhibitor used to treat specific cancers by blocking signals that promote tumor growth and blood supply.
Key facts at a glance
- ATC
- L01EX07
- RxNorm
- 1363268
- Generic
- Cabozantinib
- Class
- atc-l01
- Brands
- Cometriq, Cabometyx
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Approved for the treatment of patients with advanced renal cell carcinoma (RCC), hepatocellular carcinoma (HCC) in patients previously treated with sorafenib, and progressive, metastatic medullary thyroid cancer (MTC).
Cabozantinib inhibits multiple receptor tyrosine kinases including MET, VEGFR-1/2/3, RET, KIT, TRKB, FLT-3, AXL, ROS1, TYRO3, MER, and TIE-2, disrupting tumor cell proliferation, survival, and angiogenesis (new blood vessel formation that feeds tumors).
Common side effects include diarrhea, fatigue, decreased appetite, hand-foot syndrome, and hypertension. Serious adverse events may include GI perforation, fistula formation, and hemorrhage. Requires regular monitoring of liver function and blood pressure. Should be taken on an empty stomach at least 2 hours before or 1 hour after eating.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy