Ergotamine and Caffeine
Cafergot is a brand-name combination medication containing ergotamine tartrate and caffeine, used to treat migraine and cluster headaches. It works by constricting blood vessels in the brain and reducing inflammation associated with vascular headaches. This medication is typically prescribed for patients experiencing moderate to severe migraines, particularly those accompanied by aura.
Cafergot is a migraine medication that combines ergotamine and caffeine to relieve vascular headaches by narrowing brain blood vessels.
Key facts at a glance
- RxNorm
- 20027
- Generic
- Cafergot
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute migraine and cluster headaches, particularly when accompanied by aura or visual disturbances. Not typically used for tension headaches.
Ergotamine acts as a vasoconstrictor to narrow expanded blood vessels around the brain that contribute to migraine pain. Caffeine enhances ergotamine absorption and may also help constrict blood vessels.
Should not be used by patients with cardiovascular disease, uncontrolled hypertension, or during pregnancy. Risk of dependency with prolonged use; not recommended for daily or frequent dosing. May cause nausea, vomiting, or dizziness. Consult healthcare provider for proper dosing and contraindications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed September 3, 2026. · Read our editorial policy