Caffeine / Chlorphenoxamine
Caffeine/Chlorphenoxamine is a combination medication containing a CNS stimulant and an antihistamine agent. This multi-ingredient formulation is used for the treatment of headache disorders, particularly migraine and tension-type headaches. The combination works synergistically, with caffeine enhancing vasoconstriction and chlorphenoxamine providing antihistamine and mild analgesic effects.
A headache treatment combining caffeine with an antihistamine for migraine and tension headache relief.
Key facts at a glance
- RxNorm
- 1008211
- Generic
- Caffeine / Chlorphenoxamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for acute treatment of migraine and tension-type headaches. May also be prescribed for other headache disorders where vasoconstriction and antihistamine effects provide relief.
Caffeine acts as a central nervous system stimulant and cerebral vasoconstrictor, while chlorphenoxamine provides H1-antihistamine activity with anticholinergic properties. Together, they address multiple headache pathways including vascular and inflammatory components.
Use as prescribed; avoid in patients with cardiovascular disease, hypertension, or caffeine sensitivity. May cause drowsiness or interact with other CNS depressants. Not recommended during pregnancy without medical supervision. Limit caffeine intake from other sources to avoid excessive stimulation.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy