Caffeine / Diphenhydramine / Ergotamine
This combination medication is used to treat migraine headaches. The ergotamine component causes vasoconstriction of blood vessels in the brain, caffeine enhances the pain-relieving effects, and diphenhydramine provides relief from associated nausea and anxiety while promoting sedation.
A migraine treatment combining ergotamine, caffeine, and diphenhydramine to address headache pain, nausea, and related symptoms.
Key facts at a glance
- RxNorm
- 818740
- Generic
- Caffeine / Diphenhydramine / Ergotamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute migraine and cluster headaches, particularly those accompanied by nausea, anxiety, or sleep disturbance.
Ergotamine constricts cranial blood vessels to reverse migraine vasodilation; caffeine enhances ergotamine absorption and provides additional vasoconstrictive effects; diphenhydramine blocks histamine receptors to reduce nausea and anxiety while promoting relaxation.
Should not be used by patients with cardiovascular disease, hypertension, or pregnancy. Risk of medication overuse headache with frequent use. Not intended for long-term daily therapy. Patients should avoid other ergot derivatives while taking this medication. May cause drowsiness; avoid driving until aware of effects.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy