Caffeine / Dipyrone / Ergotamine
This combination medication is used to treat acute migraine headaches and tension-type headaches. It combines three ingredients: ergotamine (which constricts blood vessels in the brain), dipyrone (a pain-relieving and fever-reducing agent), and caffeine (which may enhance the absorption and effectiveness of the other components). This multi-ingredient approach targets both the vascular and pain pathways involved in migraines.
A combination analgesic for treating acute migraine attacks by combining vasoconstriction, pain relief, and enhanced drug absorption.
Key facts at a glance
- RxNorm
- 816825
- Generic
- Caffeine / Dipyrone / Ergotamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute migraine attacks with or without aura, and sometimes tension-type headaches. Not intended for prevention but for relief during active headache episodes.
Ergotamine causes vasoconstriction of cranial blood vessels to counteract migraine-induced dilation. Dipyrone provides analgesic and antipyretic effects through inhibition of prostaglandin synthesis. Caffeine acts as an adjuvant to improve absorption and may provide additional mild analgesic effects.
Should not be used by patients with cardiovascular disease, hypertension, peripheral vascular disease, or during pregnancy. Risk of medication-overuse headaches with frequent use. Ergotamine-containing products carry risks of ergotism and cardiac complications. Availability varies by country; not FDA-approved in the United States. Should be taken at the first sign of migraine for best effect.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy