Caffeine / Ergotamine
Caffeine/Ergotamine is a combination medication used for the acute treatment of migraine and cluster headaches. Ergotamine works as a vasoconstrictor to narrow blood vessels in the brain, while caffeine enhances its absorption and may help relieve headache pain.
A migraine medication combining ergotamine and caffeine to constrict brain blood vessels and relieve headache pain.
Key facts at a glance
- RxNorm
- 214336
- Generic
- Caffeine / Ergotamine
- Class
- multi-ingredient
- Brands
- Cafergot, Migergot
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Acute treatment of migraine and cluster headaches. Not intended for preventive use or for managing other types of pain.
Ergotamine acts as a vasoconstrictor of cranial blood vessels, reducing the pulsation thought to contribute to migraine pain. Caffeine increases ergotamine absorption and may enhance its vasoconstrictive effects.
Should be taken at first sign of headache for best effectiveness. Contraindicated in patients with cardiovascular disease, uncontrolled hypertension, or during pregnancy. Risk of medication overuse headache with frequent use. May interact with other vasoconstrictors, triptans, or certain antibiotics. Ergot derivatives can cause serious vasospastic reactions if misused.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy