Caffeine / Ergotamine / Ibuprofen
This multi-ingredient medication combines caffeine, ergotamine, and ibuprofen to treat acute migraine headaches. Ergotamine works as a vasoconstrictor to narrow blood vessels around the brain, while caffeine enhances its absorption and effects. Ibuprofen provides additional analgesic and anti-inflammatory benefits for pain relief.
A combination medication for acute migraine relief that combines vasoconstriction, enhanced absorption, and anti-inflammatory action.
Key facts at a glance
- RxNorm
- 1009128
- Generic
- Caffeine / Ergotamine / Ibuprofen
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for the acute treatment of migraine and cluster headaches, particularly those with moderate to severe pain and associated symptoms like nausea and sensitivity to light or sound.
Ergotamine constricts cranial blood vessels to counteract migraine-related vasodilation; caffeine enhances ergotamine absorption and provides vasoconstrictive effects; ibuprofen inhibits prostaglandin synthesis to reduce inflammation and pain transmission.
Typically reserved for episodic use rather than daily treatment due to risks of medication-overuse headache and ergotism with prolonged use. Contraindicated in patients with cardiovascular disease, uncontrolled hypertension, or pregnancy. Should not be used with other vasoconstrictors or within 24 hours of triptans.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy