Caffeine / Ergotamine / Belladonna Alkaloids / Pentobarbital
This combination medication contains ergotamine (a vasoconstrictor), caffeine (enhances absorption and constricts cerebral blood vessels), belladonna alkaloids (anticholinergic effects), and pentobarbital (a barbiturate sedative). It is used to treat and prevent vascular headaches, particularly migraines, by addressing multiple components of headache pathophysiology including blood vessel dilation and associated symptoms.
A migraine treatment combining ergotamine, caffeine, belladonna, and a barbiturate to prevent and relieve vascular headaches.
Key facts at a glance
- RxNorm
- 1007603
- Generic
- Caffeine / Ergotamine / Levorotatory Alkaloids Of Belladonna / Pentobarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for the treatment and prevention of vascular headaches, including migraine and cluster headaches. May be used when simpler treatments have been ineffective.
Ergotamine causes vasoconstriction of cranial blood vessels to counteract dilation during migraine attacks. Caffeine enhances ergotamine absorption and provides additional vasoconstrictive effects. Belladonna alkaloids provide anticholinergic action that may help with associated symptoms like nausea. Pentobarbital provides calming and sedative effects to help manage headache-related discomfort and anxiety.
Contains a barbiturate with potential for dependence and withdrawal symptoms. Ergot derivatives can cause serious vasoconstrictive complications including fibrosis and reduced blood flow to extremities. Contraindicated in patients with cardiovascular disease, hypertension, liver or kidney impairment, and pregnancy. Should not be used with other vasoconstrictors or ergot-containing products. May cause drowsiness; avoid operating machinery.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy