Caffeine / Hordenine
Caffeine/Hordenine is a dietary supplement combining two alkaloid compounds marketed primarily as an energy-enhancing and weight management aid. This combination is typically found in pre-workout and thermogenic supplement products. The pairing is intended to provide stimulant effects for improved alertness, exercise performance, and metabolic support.
A stimulant supplement combining caffeine and hordenine alkaloids for energy, focus, and potential metabolic benefits.
Key facts at a glance
- RxNorm
- 1008196
- Generic
- Caffeine / Hordenine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This supplement is commonly used for increasing energy and alertness, supporting exercise performance during workouts, and as part of weight management regimens. It may appeal to individuals seeking enhanced focus and reduced fatigue. Note that these uses are not FDA-approved therapeutic indications but rather supplement marketing claims.
Caffeine acts as a central nervous system stimulant by blocking adenosine receptors and increasing dopamine and norepinephrine activity. Hordenine is believed to have sympathomimetic properties and may support the release of norepinephrine. Together, they are intended to produce synergistic stimulant effects for enhanced energy and alertness.
This is a dietary supplement, not an FDA-approved medication. Common side effects may include jitteriness, anxiety, elevated heart rate, and sleep disturbances due to caffeine content. Those with cardiovascular conditions, anxiety disorders, or caffeine sensitivity should exercise caution. Consultation with a healthcare provider is recommended before use, especially for individuals on other medications or with underlying health conditions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy