Caffeine / Meclizine
Caffeine/Meclizine is a combination medication that pairs an antihistamine with a stimulant to help prevent and treat motion sickness, vertigo, and associated symptoms like nausea, vomiting, and dizziness. The meclizine component helps reduce nausea and vestibular disturbances while caffeine counteracts drowsiness and may help relieve headache symptoms. This combination is commonly used by travelers, those experiencing balance disorders, and individuals with Meniere's disease.
A motion sickness and vertigo treatment combining an antihistamine with caffeine to reduce nausea, dizziness, and drowsiness.
Key facts at a glance
- RxNorm
- 1008648
- Generic
- Caffeine / Meclizine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for prevention and treatment of motion sickness during travel (car, boat, plane), as well as management of vertigo and dizziness associated with vestibular disorders like Meniere's disease. Also helps relieve associated symptoms such as nausea, vomiting, and headache.
Meclizine is an antihistamine that works on the vestibular system to reduce signals that trigger nausea and dizziness. Caffeine acts as a mild stimulant to counteract the sedating effects of antihistamines and may help relieve tension headaches that can accompany motion sickness.
May cause drowsiness; avoid driving or operating machinery until you know how it affects you. Should not be combined with alcohol or other CNS depressants. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications. Less effective if taken after symptoms have already become severe.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy