Caffeine Monohydrate
Caffeine Monohydrate is the hydrated crystalline form of caffeine, a methylxanthine compound that acts as a central nervous system stimulant. It is commonly used as a mild cognitive enhancer and is found in many over-the-counter products for alertness and energy. Additionally, it serves as an analgesic adjuvant in certain combination medications for headache relief.
A CNS stimulant used to enhance alertness and as an adjuvant in headache medications.
Key facts at a glance
- RxNorm
- 236112
- Generic
- Caffeine Monohydrate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for temporary relief of drowsiness and fatigue, as an analgesic adjuvant in combination headache products (such as with acetaminophen or aspirin), and occasionally for neonatal apnea in specific medical settings.
Functions as a non-selective antagonist of adenosine receptors in the brain, blocking the inhibitory effects of adenosine which leads to increased neuronal firing and release of neurotransmitters like dopamine and norepinephrine. Also promotes cyclic AMP accumulation through phosphodiesterase inhibition.
May cause insomnia, anxiety, palpitations, or gastrointestinal distress. Should be used cautiously in individuals with cardiovascular conditions, anxiety disorders, or caffeine sensitivity. Avoid combining with other stimulants. Consult a healthcare provider before use during pregnancy or breastfeeding.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy