Caffeine / Nitroglycerin
Caffeine/Nitroglycerin is a multi-ingredient medication combining a central nervous system stimulant with a nitrate vasodilator. This combination may be used for certain headache disorders, particularly tension-type headaches or vascular headaches, where the vasodilatory properties of nitroglycerin and the stimulant effects of caffeine work together. The specific indications and formulation details can vary by country and manufacturer.
A combination medication containing caffeine and nitroglycerin, potentially used for headache management.
Key facts at a glance
- RxNorm
- 817255
- Generic
- Caffeine / Nitroglycerin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
May be prescribed for tension headaches, vascular headaches, or other pain conditions as determined by a healthcare provider. Not a first-line treatment for angina (a common nitroglycerin use alone).
Nitroglycerin is a nitrate that releases nitric oxide, causing vasodilation and reduced cardiac workload. Caffeine is a methylxanthine stimulant that affects adenosine receptors and can enhance analgesic effects. The combination may address both vascular and muscular components of certain headaches.
Should not be used by patients taking other nitrates, PDE-5 inhibitors, or with severe hypotension. Caffeine may cause dependency or interact with other stimulants. Avoid alcohol. This combination may not be widely available; consult a pharmacist for specific product availability.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy