Caffeine / Pheniramine / Phenylephrine / Salicylic Acid
This multi-ingredient medication combines an antihistamine (pheniramine), decongestant (phenylephrine), NSAID (salicylic acid), and stimulant (caffeine) to provide relief from multiple cold and flu symptoms simultaneously. It is designed for short-term treatment of respiratory illnesses involving congestion, sneezing, runny nose, headache, minor pain, and fatigue.
A combination cold and flu remedy addressing congestion, allergies, pain, and fatigue through multiple active ingredients.
Key facts at a glance
- RxNorm
- 1008492
- Generic
- Caffeine / Pheniramine / Phenylephrine / Salicylic Acid
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of cold, flu, or allergic symptoms including nasal congestion, runny nose, sneezing, watery eyes, headache, minor aches and pains, and fatigue associated with these conditions.
Phenylephrine constricts blood vessels in nasal passages to reduce congestion; pheniramine blocks histamine receptors to relieve allergic symptoms; salicylic acid reduces inflammation and pain; caffeine provides stimulant effects to combat fatigue and may enhance analgesic effects.
Use caution in patients with cardiovascular disease, hypertension, glaucoma, thyroid disorders, or prostate enlargement. Avoid combining with other caffeine sources or alcohol. Salicylic acid component may cause stomach irritation. Not recommended for use in children due to Reye's syndrome risk if flu symptoms are present. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy