Caffeine / Phenobarbital
Caffeine/Phenobarbital is a combination medication that pairs a central nervous system stimulant with a barbiturate sedative. This multi-ingredient formulation has been used in the management of certain headache disorders, particularly tension-type headaches, where caffeine may enhance analgesic effectiveness while phenobarbital provides sedative and anticonvulsant effects. The combination represents a unique approach that balances stimulant and depressant properties of the central nervous system.
A combination CNS stimulant and barbiturate used primarily for headache management and certain neurological conditions.
Key facts at a glance
- RxNorm
- 1008949
- Generic
- Caffeine / Phenobarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for tension-type headaches and as an analgesic adjuvant. May also be prescribed for seizure disorders where phenobarbital's anticonvulsant properties are beneficial. The caffeine component may enhance the effectiveness of accompanying analgesics.
Phenobarbital acts as a GABA-A receptor agonist, increasing inhibitory neurotransmission to produce sedation and anticonvulsant effects. Caffeine is a non-selective adenosine receptor antagonist that stimulates the central nervous system, potentially counteracting sedation while enhancing analgesic effects.
Use of barbiturates carries risks of dependence, tolerance, and withdrawal. May cause drowsiness or dizziness; avoid operating machinery. Should not be combined with alcohol or other CNS depressants without medical supervision. Abrupt discontinuation should be avoided due to withdrawal risks. Regular monitoring may be required for long-term use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy