Caffeine / Phenylpropanolamine
Caffeine/Phenylpropanolamine is a combination medication historically used as an appetite suppressant for weight management and as a nasal decongestant. Caffeine acts as a mild stimulant while phenylpropanolamine works as a sympathomimetic agent to reduce nasal congestion and suppress appetite. This medication was commonly marketed for short-term weight loss aid and relief of cold or allergy-related nasal stuffiness.
A former OTC weight loss aid and decongestant combining a stimulant with a nasal decongestant.
Key facts at a glance
- RxNorm
- 820115
- Generic
- Caffeine / Phenylpropanolamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Short-term weight management (appetite suppression) and temporary relief of nasal congestion due to colds, hay fever, or allergies. Note: This formulation has been withdrawn from many markets due to safety concerns.
Caffeine provides mild stimulant effects that may modestly suppress appetite and increase metabolism. Phenylpropanolamine is an alpha-adrenergic agonist that causes vasoconstriction in nasal passages, reducing swelling and congestion, and may also contribute to reduced appetite through central nervous system effects.
Phenylpropanolamine has been associated with increased risk of hemorrhagic stroke and was removed from many markets. This medication should not be used by individuals with cardiovascular disease, hypertension, thyroid disorders, or glaucoma. Avoid combining with other stimulants or MAO inhibitors. Discontinue use and seek medical attention if chest pain, severe headache, or neurological symptoms occur. Not recommended for extended use.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy