Caffeine / Propyphenazone
Caffeine/Propyphenazone is a combination analgesic medication that combines caffeine with propyphenazone, an NSAID-related analgesic. This medication is primarily used for the relief of mild to moderate pain such as headaches, toothaches, and menstrual cramps, with caffeine added to enhance the pain-relieving effectiveness of propyphenazone.
A combination analgesic pairing caffeine with propyphenazone for enhanced relief of mild to moderate pain.
Key facts at a glance
- RxNorm
- 1008828
- Generic
- Caffeine / Propyphenazone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to relieve mild to moderate pain including headaches, toothache, menstrual pain, neuralgia, and musculoskeletal pain. Also sometimes used for fever reduction.
Propyphenazone provides analgesic and antipyretic effects through inhibition of prostaglandin synthesis. Caffeine acts as a mild stimulant and is believed to enhance the analgesic effect of propyphenazone by increasing its absorption and vasoconstriction, potentially providing faster and more effective pain relief.
This combination should be used with caution in individuals with cardiovascular problems, anxiety disorders, or caffeine sensitivity. Like other NSAIDs, propyphenazone may cause gastrointestinal irritation. Not recommended during pregnancy without medical consultation. Avoid excessive caffeine intake while taking this medication.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy