Diphenhydramine
Caladryl Clear is an over-the-counter topical skin medication used to relieve itching, irritation, and minor skin rashes from conditions like poison ivy, insect bites, and sunburn. It is applied directly to the skin and is typically formulated as a clear lotion for discreet use.
Topical anti-itch lotion for relieving minor skin irritations and rashes.
Key facts at a glance
- RxNorm
- 215812
- Generic
- Caladryl Clear
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Caladryl Clear is used to relieve itching, redness, and irritation from minor skin conditions including poison ivy, poison oak, poison sumac, insect bites, sunburn, and other non-serious skin irritations.
The exact mechanism is not specified; however, Caladryl products typically contain active ingredients like calamine and/or pramoxine that work as astringents and topical anesthetics to soothe irritated skin and temporarily numb itching.
For external use only. Avoid contact with eyes and mucous membranes. Do not use on broken or blistered skin unless directed by a healthcare provider. Discontinue use and consult a doctor if symptoms worsen or persist beyond 7 days. Keep out of reach of children.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed September 3, 2026. · Read our editorial policy