Calamine / Camphor / Diphenhydramine
This combination topical medication contains calamine, camphor, and diphenhydramine to provide relief from itching and minor skin irritations. Calamine acts as a skin protectant, camphor provides a cooling sensation that distracts from itch, and diphenhydramine is an antihistamine that addresses histamine-related itching. This product is commonly used for insect bites, poison ivy, oak or sumac exposure, and other itchy skin conditions.
A topical anti-itch treatment combining three ingredients to soothe and relieve minor skin irritations from insect bites, poison ivy, and similar causes.
Key facts at a glance
- RxNorm
- 690835
- Generic
- Calamine / Camphor / Diphenhydramine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of itching associated with insect bites, poison ivy, poison oak, poison sumac, and other minor skin irritations. May also be used for sunburn, eczema, or chickenpox-related itching.
The three ingredients work through complementary mechanisms: calamine coats and protects irritated skin while providing a soothing effect; camphor creates a cooling sensation that serves as a counter-irritant to reduce the perception of itching; diphenhydramine is an antihistamine that blocks histamine, a key chemical involved in allergic itching responses.
For external use only. Avoid applying to large areas of skin, open wounds, or broken skin. Do not use tight bandages over the treated area. Consult a healthcare provider before use in children under 2 years. Discontinue use and seek medical attention if symptoms worsen or persist beyond 7 days. Avoid contact with eyes and mucous membranes.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy