Calamine / Diphenhydramine
Calamine/Diphenhydramine is a topical combination medication used to relieve itching and skin irritation. Calamine provides a cooling sensation and protective barrier on the skin, while diphenhydramine is an antihistamine that reduces itching by blocking histamine receptors. This combination is commonly used for conditions like poison ivy, sunburn, and minor skin rashes.
A topical anti-itch medication combining calamine and an antihistamine for relief of minor skin irritations and allergic reactions.
Key facts at a glance
- RxNorm
- 690837
- Generic
- Calamine / Diphenhydramine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats itching and irritation from poison ivy, oak, sumac, insect bites, sunburn, eczema, and other minor skin conditions causing pruritus.
Calamine acts as an astringent and provides a cooling sensation on the skin, while diphenhydramine blocks histamine H1 receptors to reduce itching and inflammation associated with allergic reactions.
For external use only; avoid applying to large areas of skin or broken skin. Consult a healthcare provider before use in children under 2 years. Discontinue use and seek medical attention if symptoms worsen or persist beyond 7 days.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy