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Calamine / Menthol / Petrolatum / Zinc Oxide

Published: July 27, 2026Updated: August 28, 2026

This combination topical medication provides multiple skin-protecting and soothing benefits. Calamine and menthol help relieve itching and irritation, while petrolatum forms a protective barrier and zinc oxide provides soothing and mild protective properties. This product is commonly used for diaper rash, minor skin irritations, and dry or chapped skin.

Quick summary

A topical skin protectant and anti-itch medication commonly used for diaper rash and minor skin irritations.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 28, 2026Editorial policy

Key facts at a glance

RxNorm
1249116
Generic
Calamine / Menthol / Petrolatum / Zinc Oxide
Class
multi-ingredient
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

Treatment and prevention of diaper rash, relief of minor skin irritations, itching from sunburn or other causes, dry or chapped skin, and as a protective barrier for sensitive skin areas.

Calamine and menthol provide cooling and anti-itch effects; petrolatum creates an occlusive barrier to lock in moisture and protect skin; zinc oxide offers soothing and mild protective properties.

For external use only. Avoid contact with eyes and mucous membranes. Do not use on deep or infected wounds. Discontinue use and consult a healthcare provider if irritation, redness, or worsening symptoms occur. Not recommended for use on extensive areas of broken skin without medical guidance.

Official drug label

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy