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Calamine / Phenol / Zinc Oxide

Published: July 27, 2026Updated: August 28, 2026

This topical medication combines calamine, phenol, and zinc oxide to soothe minor skin irritations, itching, and rashes. It is commonly used for conditions such as sunburn, insect bites, and poison ivy. The combination provides both protective and symptomatic relief for various skin conditions.

Quick summary

A topical combination medication that soothes itching and protects skin from minor irritations like sunburn and insect bites.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 28, 2026Editorial policy

Key facts at a glance

RxNorm
690841
Generic
Calamine / Phenol / Zinc Oxide
Class
multi-ingredient
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

Treats minor skin irritations, itching (pruritus), sunburn, insect bites and stings, poison ivy/oak, and various rashes. Often used for general skin discomfort and itching from multiple causes.

Zinc oxide forms a protective barrier on the skin's surface. Calamine has soothing and anti-itch properties. Phenol provides mild antiseptic and local anesthetic effects. Together they help reduce itching, protect irritated skin, and prevent further irritation from external sources.

For external use only—avoid contact with eyes and mucous membranes. Do not apply to broken or infected skin. Discontinue use if severe irritation, rash, or allergic reaction occurs. Consult a healthcare provider if symptoms persist beyond 7 days or worsen. Keep out of reach of children.

Official drug label

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy