Calamine / Pramoxine
Calamine/Pramoxine is a topical combination medication that provides relief from itching, pain, and discomfort associated with various skin irritations. It contains pramoxine, a local anesthetic that temporarily numbs the skin, and calamine, which soothes and protects irritated skin. This medication is commonly used for conditions like poison ivy, insect bites, minor burns, and sunburn.
Topical medication combining an anesthetic and skin-soothing agent to relieve itching and pain from skin irritations.
Key facts at a glance
- RxNorm
- 804304
- Generic
- Calamine / Pramoxine
- Class
- multi-ingredient
- Brands
- Caladryl, Calagesic
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Relief of itching, pain, and irritation from poison ivy/oak/sumac, insect bites, minor burns, sunburn, eczema, chickenpox, and other skin irritations. May also be used for general pruritic (itchy) skin conditions.
Pramoxine is a topical anesthetic that blocks nerve signals in the skin to temporarily relieve itching and pain. Calamine acts as an astringent and skin protectant, helping to soothe irritation and create a protective barrier on the skin.
For external use only. Avoid contact with eyes, mouth, and sensitive areas. Do not apply to broken or blistered skin unless directed by a healthcare provider. Discontinue use if rash, irritation, or allergic reaction occurs. Consult a doctor before use in children under 2 years of age. Shake well before use if using a lotion formulation.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy