Calcifediol Anhydrous
Calcifediol Anhydrous is a hydroxylated form of vitamin D that serves as a precursor to the active hormone calcitriol. It is primarily used to treat secondary hyperparathyroidism and vitamin D deficiency, particularly in patients with chronic kidney disease who have impaired conversion of vitamin D to its active form.
Calcifediol Anhydrous is a vitamin D prohormone used to treat vitamin D deficiency and secondary hyperparathyroidism, particularly in chronic kidney disease patients.
Key facts at a glance
- RxNorm
- 1855064
- Generic
- Calcifediol Anhydrous
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Treatment of secondary hyperparathyroidism associated with chronic kidney disease, vitamin D deficiency, and conditions requiring supplementation of vitamin D metabolites when standard vitamin D is insufficient.
Calcifediol is converted in the kidneys to calcitriol (1,25-dihydroxyvitamin D3), the active form that increases intestinal calcium absorption, enhances renal calcium reabsorption, and works with parathyroid hormone to regulate calcium and phosphorus homeostasis.
Requires monitoring of serum calcium and phosphorus levels due to risk of hypercalcemia. Use cautiously in patients with kidney stones, hypercalcemia, or those taking thiazide diuretics or cardiac glycosides. Not suitable for patients requiring strict phosphorus restriction without careful supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy