Calcium Chloride
Calcium Chloride is an electrolyte replacement medication used to treat low blood calcium levels (hypocalcemia) and calcium deficiency conditions. It is also used in cardiac resuscitation scenarios as a calcium channel agent and in the treatment of certain poisonings, including those from calcium channel blockers or beta-blocker overdoses.
Calcium Chloride is an essential electrolyte supplement used to treat low blood calcium and support cardiac function during emergencies.
Key facts at a glance
- ATC
- A12AA07
- RxNorm
- 1901
- Generic
- Calcium Chloride
- Class
- atc-a12
- Brands
- Clinimix E 4.25/10, Extraneal, Nutrilyte II, Dianeal PD-2/4.25, Dianeal PD-2/2.5, Dianeal PD-2/1.5, Dianeal Low Calcium 1.5, Dianeal Low Calcium 4.25, Dianeal Low Calcium 2.5, Clinimix E 4.25/5, Clinimix E 2.75/5, Clinimix E 5/15, Clinimix E 5/20, Clinimix E 5/25, BSS Ophthalmic Solution
- Availability
- rx
- Lactation
- unknown
- Routes
- ophthalmic
- Forms
- injection, prefilled syringe, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 2.5 mEq/L calcium
- Maximum
- consult physician
- Frequency
- continuous infusion during dialysis
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 1.5 mEq/L calcium
- Maximum
- consult physician
- Frequency
- continuous infusion during dialysis
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 2.0 mEq/L calcium
- Maximum
- consult physician
- Frequency
- continuous infusion during dialysis
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
6 groupspregnancy
all trimestersuse lowest effective dose
use only when clearly needed for calcium replacement; benefits of adequate calcium intake may outweigh risks
monitor serum calcium levels regularly
Use with caution and monitor for adverse effects.
lactation
breastfeedingno adjustment needed
calcium supplementation is generally safe and may be beneficial
routine maternal serum calcium monitoring if high doses used
pediatric_age
neonates infantsweight-based dosing required; reduce dose proportionally
use under close medical supervision; avoid rapid infusion
continuous cardiac monitoring; frequent serum calcium checks
Use with caution and monitor for adverse effects.
geriatric
elderly 65start with lower dose, titrate slowly
assess renal and cardiac function before use; avoid rapid infusion
monitor renal function, serum calcium, ECG, blood pressure
Use with caution and monitor for adverse effects.
renal_impairment
mild moderatereduce dose and monitor closely
use with caution; monitor serum calcium frequently
frequent serum calcium, phosphorus, creatinine monitoring
Use with caution and monitor for adverse effects.
hepatic_impairment
mild moderateno specific adjustment; monitor electrolytes
use standard dosing with monitoring
monitor serum calcium, liver function tests
Use with caution and monitor for adverse effects.
Statistics and clinical data
Commonly prescribed since
General prescribing information for calcium chloride solutions
Drug class
Drug class information for calcium chloride
Common uses
Common therapeutic uses
Mechanism of action
Pharmacological mechanism
Treatment and prevention of hypocalcemia, electrolyte replacement, cardiac resuscitation, magnesium sulfate overdose, calcium channel blocker or beta-blocker toxicity, and as an adjunct in hyperkalemia management.
Calcium Chloride provides ionized calcium, an essential cation critical for bone structure, neuromuscular function, blood coagulation, and cardiac contractility. It works by rapidly increasing serum calcium levels.
Administered intravenously with caution in patients on digoxin (risk of arrhythmias), requires careful monitoring of calcium levels, and may cause tissue necrosis if extravasation occurs. Generally not administered intramuscularly or subcutaneously.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy