Calcium Polystyrene Sulfonate Product / Methylcellulose
Calcium Polystyrene Sulfonate with Methylcellulose is a combination medication used to treat hyperkalemia (elevated blood potassium levels). The calcium polystyrene sulfonate component binds to potassium in the intestines, while methylcellulose adds bulk and promotes regular bowel movements to prevent constipation, a common side effect of the resin. This medication is typically prescribed for patients with chronic kidney disease or other conditions causing impaired potassium excretion.
A combination medication that lowers high blood potassium levels while preventing constipation associated with potassium-binding resins.
Key facts at a glance
- RxNorm
- 1008140
- Generic
- Calcium Polystyrene Sulfonate Product / Methylcellulose
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of hyperkalemia (elevated blood potassium), particularly in patients with chronic kidney disease, end-stage renal disease on dialysis, or conditions causing impaired potassium excretion. May also be used in situations where ongoing potassium management is needed.
Calcium polystyrene sulfonate is a cation exchange resin that releases calcium ions in exchange for potassium and ammonium ions in the gastrointestinal tract, allowing excess potassium to be excreted in feces. Methylcellulose, a bulk-forming agent, adds soluble fiber to the stool, promoting bowel regularity and preventing the constipation commonly caused by the resin.
May cause constipation, electrolyte disturbances (low calcium or high potassium in some cases), or gastrointestinal discomfort. Take as directed with meals and adequate fluids. Drug interactions are common as the resin can bind many oral medications; separate dosing by several hours. Not recommended for acute, severe hyperkalemia requiring emergency intervention. Monitor electrolyte levels regularly during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy