Caplacizumab
Caplacizumab is a monoclonal antibody that targets von Willebrand factor (vWF) to prevent abnormal clot formation. It is used to treat adults experiencing episodes of acquired thrombotic thrombocytopenic purpura (aTTP), a rare blood disorder, typically administered alongside plasma exchange and immunosuppressive therapy.
Caplacizumab treats acquired thrombotic thrombocytopenic purpura (aTTP) by blocking von Willebrand factor-platelet interactions to reduce clot formation and platelet consumption.
Key facts at a glance
- ATC
- B01AX07
- RxNorm
- 2110605
- Generic
- Caplacizumab
- Class
- atc-b01
- Brands
- Cablivi
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Caplacizumab is indicated for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in adults, used in combination with plasma exchange and immunosuppressive therapy.
Caplacizumab specifically targets the A1 domain of von Willebrand factor (vWF), blocking its interaction with platelet glycoprotein Ib. This inhibits vWF-mediated platelet adhesion and reduces excessive platelet consumption, which are hallmarks of aTTP.
Common adverse reactions include bleeding complications such as nosebleeds, gum bleeding, and bruising. Caplacizumab is administered as a subcutaneous injection. Patients should be monitored closely for signs of bleeding, particularly when used concurrently with anticoagulants. Treatment is typically continued for a period after plasma exchange is completed.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy